I also posted the Newcastle 600 calorie diet research which showed reversal of diabetes.
So just to summarise.
If you have diabetes - Try the 600 calorie diet or other ways to reverse
If you don’t have diabetes, try to eat less sugar and carbs so you don’t cause self-inflicted type 2 diabetes
If all else fails, pump yourself with this new drug 
Oops @nz, that was for you
600 claories is some extreme dieting, All Bran for breakfast , lunch and dinner with soya been milk and a few carrots should do it. 
From memory, 6 weeks on the 600 calorie diet reversed diabetes in people quite significantly.
Lots of YT vids on eating well for 600 calories. The toughest is the 1st few days where your body (and mind) craves for food. Also, no need for 3 meals a day 1-2 meals a day is fine. That notion of 3 meals a day again was just marketing way back when. 16-8 or even 20-4 eating regimes work as well.
For some reason the article crashes my browser, but I don’t see how this could possibly work. People are diabetic because they eat a relentless diet of shite, and they eat that diet because they are diabetic; they’re compelled to do it. It’s an interesting example of a biological control loop with insufficient phase margin (it can’t cope with modern processed foods). If you stop eating like that and start eating proper food, diabetes goes away - although of course you have to catch it early enough, before glucose toxicity starts to take its toll.
The control group in a clinical trial should be the best available alternative treatment, which in the case of T2D is a low-carb diet. Those results would be easily matched by a simple dietary intervention.
The question here is: what’s the mechanism? If their diet is unchanged, then the drug can only work by moving glucose somewhere it should not go, which will ultimately result in disease and death. HbA1C is a proxy for diabetes; it does not define the disease. This looks a lot like the clinical trials for statins, which can legitimately claim dramatic reductions in LDL-C, but have virtually no impact on cardiovascular disease.
There’s no actual need to do this, but doctors love to push draconian therapies because it maintains the mysticism of medicine (and some patients love it too, so if it works for some, I won’t knock it). It works because the Newcastle diet reduces carb-calories to a low enough level that your body starts to look elsewhere for energy; the concurrent reduction of protein+fat is pointless at best (and seems to cause a high dropout rate, if you look at the research). For the vast majority all you need to do is replace carb-calories with fat-calories, and eat to appetite. This allows your glucose management to recalibrate, you stop craving donuts and Coke, and most people find it easy to stick to from there.
It’s a well known diagnostic biomarker for diabetes.
That along with the weight loss makes this look like an effective drug. Would need to follow up the patients long term in terms of their blood sugar levels and insulin production .
Yes, I know it’s a biomarker. It is not the disease itself. Once your body runs out of places to dump glucose-based energy, it starts to dump it into your red blood cells as a last resort. If you prevent that from happening then, logically, that glucose has to go somewhere else. It’s just physics. Or chemistry.
If you reduce A1C without making any changes to the diet, that does not constitute a cure for diabetes. I’d go so far as to say that no drug-based cure is possible.
EDIT: I get it, it appears to work by modifying appetite, not glucose regulation. Sensible, but completely pointless, since you can do that without the use of drugs.
Did you miss the part that this drug is an appetite suppressor ? Did you actually read about what the drug is doing ?
They simply aren’t eating as much.
Pays to read before going off like a loose cannon.
Yeah, I just read the second link. I still suspect it’s another scam in the making, since (as per the Daily Mail article) it’ll probably be pushed as a (very expensive) “alternative” to surgery, ie., patients will be presented with a false dichotomy and strongly discouraged from just changing their eating habits.
Patients are always encouraged to change their eating habits. It doesn’t work for the vast majority of them.
No, they’re not. I have a sorry list of stories of people being told not to eat healthy diets - in several cases warned that terrible things will happen if they even try it - by people who should know better. The usual culprits are nurses and ‘nutritionists’ in diabetic clinics, not doctors.
The mainstream advice is designed to keep diabetics diabetic, so that they can be railroaded through an ever-more-unpleasant (and profitable) treatment pathway.
If you don’t believe me, go and visit a diabetic clinic and ask them for one of their advice handouts. You’ll be given something that’s guaranteed to make the condition worse.
600 calories is starvation diet. One single biandan has anywhere from 800-1200 calories, and this is a small one too!
You can’t have lasting change eating 600 calories for only a few weeks, you have to do this basically for the rest of your life. You will starve much sooner than that, and/or your basic instinct will take over and you’ll go back to eating what you have always eaten. Then you are just yoyo dieting.
This is becoming another how to lose weight thread.
I’d join in, but I know how to stay at a healthy weight. Interestingly, people have started calling me skinny when in fact I am a perfectly normal weight. Normal is now skinny.
Fantastic amounts of money can be made from people who can be kept on a knife-edge of chronic illness for decades. There does seem to be a concerted effort to normalize this state of affairs.
I view it as more of a random, but inevitable, incremental phenomenon. Add more fructose, sales increase. Remove people’s stomachs, surgeons keep jobs. Make a magic pill, big profit.
Successfully get people to eat sensibly, nobody gains other than the patient. In fact, food companies lose.
Millions fail to adapt their diets or reduce their intake every year. Obesity trends have not been improving but worsening. I reckon this drug could be a game changer. It works.
Indeed. A fortuitous confluence of circumstances that can really end in only one way.
Amphetamines were more fun. But, fingers crossed with this drug
Because they’re doing it wrong; and they do it wrong because they’re explicitly instructed to do it wrong.
‘Reducing your intake’ will make you fat.
This is just more of the ‘take your pill/injections and don’t be stupid’ messages that we’ve been subjected to over the last 18 months of COVID. The idea that human bodies might work just fine if we would only leave them alone and stop fiddling with the way they work is an idea that must be stamped out.
Whatever man.
Your miracle cure is not being taken up.
This drug looks like it works. Appetite suppression is already achieved by surgery and using a drug would seem much safer…Hopefully we’ll have more effective pills to reduce alcohol or drug dependency in the near future.