Amazing this one is not higher up on the News feeds. It is still in trial but looks world changing.
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Fascinating, hope it lives up to the promise.
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Stopping eating is the best cure to being obese. Nothing is better.
The best, but not the easiest.
This has been talked about in the bodybuilding world. I’m not sure it will help a lot of fatties though. They don’t eat because they are hungry.
Hope it helps though. The current treatments are not putting a dent into the numbers.
4.5 million with diabetes in the Uk. Holy shit.
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Then why do they eat ? I know, to feel better in some cases. But you won’t feel better if you aren’t getting any reward for eating.
I think this is going to have a huge impact. Appetite suppression that is safe and effective along with regulating insulin and glycemia fairly well. Fifty years of failed strategies could be bulldozed away with this drug.
The drug (I think it may be an injection not pill as it is a chimeric peptide ) actually resulted in average weight loss of 8%-10% of body weight and many of those who took it in the trial became non diabetic. All showed significant improvement in HB1AC. The placebo had no effect basically.
Another article regarding weight loss. The problem has always been that achieving long term weight loss has always been very difficult for most people.
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Boredom? depression…
Many fat people eat well past the point of being full. To the point of throwing up and then they still keep eating. I am talking about some of the 400+ pounders. It isn’t even about the taste for some.
This drug looks very good though and it will help a lot of people. Obviously most people just overeat a little every day and it builds up over years. Game Changer for them.
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In fact if this drug is as good as it seems to be it could be widely used by the general population to lose weight. Prescribed or unprescribed.
Yes, amazing news. I wonder how long we will need to know if this reverses diabetes not just controls it. Anyone creating a cure to reverse diabetes merits a Nobel prize.
The trial results indicated a significant number of people were declared non diabetic .That seemed to be a reduction to below 5.7% HB1AC ratio.
The question would be…Do they still need to take it long term…
This article was a pretty good for explaining how it works . Quite interesting .
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00217-5/fulltext
This one summarises the astonishingly good results.
In SURPASS-1 , all three tirzepatide doses demonstrated statistically significant and clinically meaningful improvements in A1C and body weight reductions compared to placebo. Up to 92% of participants on tirzepatide achieved an A1C of less than 7%—the ADA’s recommended target for most people with diabetes. Up to 52% achieved an A1C of less than 5.7%—the level for people without diabetes
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This is available now i think. Pretty expensive though. I saw a guy who is in Thailand who could get it. Just incase anyone wants to try now.
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A video on it.
The best comment on that video.
These drugs are fascinating. They beat my idea of putting people on anesthesia and fasting them for a month.
Also
I can confirm, I started using liraglutide when I was weighing 124kg, In a month I lost 9kg because of how much I was eating and then 4 more kg the next month. I eventually stopped using because it’s expensive and my appetitte had decreased permanently. After losing the initial 12kg I proceeded to lose 18kg more over a year and now I weigh around 95-93kg. It isn’t ideal for my height(180cm) but I’m not super obese anymore. This shit really works, for me it felt like any small portion of food made me super full like I ate an entire pizza by myself.
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Sugar. The problem is sugar. We have known the problem is sugar for as long as I’ve been alive.
I know so many pre diabetics who drink a 6 pack of diet soda every morning. They accompany this with a bowl of sugary cereal with milk.
And they insist their doctors don’t know what’s wrong with them or why they can’t loose weight.
I am often criticized by people I know in the US for being “skinny”. As I’ve gotten older and gained a healthy amount of weight (though I’m still very skinny), I’ve thought about my lifestyle vs. that of people who I know bordering on or already obese. They drink sugary garbage daily and snack on high sugar foods instead of eating proper meals. I drink coffee with little or no sugar + milk or cream in the morning and water throughout the day. Maybe once or twice a week I’ll treat myself to soda or bubble tea.
The cure is very simple: highly processed, high-sugar content foods should be taxed in such a way that they cost at least two times more than the same serving of fresh fruits and vegetables. There would be no obesity or diabetes in the world if this happened. There is no need for a drug. The pharmaceutical industry, which owns Congress and the justice department, along with the packaged food industry, knows this.
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True, although modern day fruits and vegetable are being selectively bred to be sweeter and sweeter. Some fruits should be avoided unless in small quantities.
Even a high sugar fruit is nothing bad to the body compared to any processed food with added sugar. The fruit is still slowly releasing into the body. The processed sugar food is spike followed by immediate crash.
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I’m sure we all know excess carbs turns into sugar… Isn’t it better to eat selectively, rather than pump more drugs into yourself to control?
It’s not just about stopping eating, it’s about the foods we put into our mouths.
My dad is skinny and looks relatively health for an 80 year old but eats rice 3 meals a day and suffers with type 2 diabetes. Cut out the carbs (not all ofc) and you’ll see that diabetes will reduce/disappear.
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It’s not JUST sugar… It’s carbs as well. Excess carbs converts to sugar.
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When there was a food shortage and rationing had to happen for most during WWII, diabetes cases fell significantly.
obviously the food you put in your mouth matters. Most type 2 diabetics are not like your dad though. Eating rice three times a day but keeping at a healthy weight wouldn’t create diabetics. Asians have been doing that for a while. They are diabetics because they are overweight. they have metabolic syndrome. Losing weight will solve that the fastest. Doesn’t the article about ww2 show exactly that? Long term, they should of course change their diet and eat less carbs. When you haven’t got metabolic syndrome, the body is pretty adaptable.
having the self discipline to eat less or taking a drug to reduce your hunger is the same in the end.
If people had the discipline, the drug wouldn’t be needed though, would it?
You keep saying it is better to eat selectively(Less carbs) and then posted a study saying that diabetes decreased in ww2 because people had less to eat and another one saying a low calorie diet controls diabetes.
So the most important thing is to eat less and lose the weight, right?
i agree that less carbs is the way to go though.
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I know, you are replying to the wrong poster.